2022 Conference USA Leaders Sacks - Games vs. FBS non-Power 5 Conference Teams Only through 01/09/2023
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Middle Tennessee | 11 | 31.0 | 232 | 2.82 |
| 2 | UTEP | 11 | 26.0 | 176 | 2.36 |
| 3 | Western Kentucky | 11 | 23.0 | 157 | 2.09 |
| 4 | UTSA | 12 | 24.0 | 159 | 2.00 |
| 5 | North Texas | 13 | 25.0 | 159 | 1.92 |
| 6 | UAB | 11 | 21.0 | 136 | 1.91 |
| 7 | Rice | 11 | 18.0 | 128 | 1.64 |
| 7 | Florida International | 11 | 18.0 | 106 | 1.64 |
| 9 | Charlotte | 9 | 14.0 | 82 | 1.56 |
| 10 | Florida Atlantic | 10 | 15.0 | 80 | 1.50 |
| 11 | Louisiana Tech | 9 | 12.0 | 86 | 1.33 |