2022 Conference USA Leaders Sacks - Games vs. Unranked Teams Only (AP Poll) through 01/09/2023
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Middle Tennessee | 13 | 36.0 | 265 | 2.77 |
| 2 | Western Kentucky | 13 | 28.0 | 199 | 2.15 |
| 3 | UTEP | 12 | 28.0 | 186 | 2.33 |
| 4 | North Texas | 14 | 27.0 | 174 | 1.93 |
| 5 | Rice | 12 | 23.0 | 164 | 1.92 |
| 6 | UAB | 12 | 24.0 | 140 | 2.00 |
| 7 | UTSA | 12 | 19.0 | 125 | 1.58 |
| 8 | Florida International | 12 | 21.0 | 124 | 1.75 |
| 9 | Louisiana Tech | 11 | 15.0 | 97 | 1.36 |
| 10 | Florida Atlantic | 12 | 18.0 | 90 | 1.50 |
| 11 | Charlotte | 11 | 16.0 | 88 | 1.46 |