2022 Conference USA Leaders Opponent First Downs - Games vs. FBS Power 5 Conference Teams Only through 01/09/2023
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Florida Atlantic | 1 | 9 | 8 | 4 | 21 | 21.0 |
| 1 | UTSA | 1 | 12 | 8 | 1 | 21 | 21.0 |
| 3 | UTEP | 1 | 14 | 7 | 2 | 23 | 23.0 |
| 3 | Western Kentucky | 2 | 19 | 22 | 5 | 46 | 23.0 |
| 5 | Middle Tennessee | 1 | 7 | 14 | 5 | 26 | 26.0 |
| 6 | Rice | 1 | 11 | 14 | 2 | 27 | 27.0 |
| 6 | Charlotte | 2 | 24 | 27 | 3 | 54 | 27.0 |
| 6 | Louisiana Tech | 2 | 31 | 20 | 3 | 54 | 27.0 |
| 9 | UAB | 1 | 15 | 13 | 3 | 31 | 31.0 |