2022 Conference USA Leaders Rushing Defense - Games vs. FBS Power 5 Conference Teams Only through 01/09/2023
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Rice | 1 | 28 | 208 | 7.43 | 4 | 28.00 | 208.00 |
| 2 | Charlotte | 2 | 68 | 488 | 7.18 | 9 | 34.00 | 244.00 |
| 3 | Florida Atlantic | 1 | 36 | 188 | 5.22 | 1 | 36.00 | 188.00 |
| 3 | UTSA | 1 | 36 | 298 | 8.28 | 3 | 36.00 | 298.00 |
| 5 | Middle Tennessee | 1 | 38 | 60 | 1.58 | 2 | 38.00 | 60.00 |
| 5 | UTEP | 1 | 38 | 259 | 6.82 | 4 | 38.00 | 259.00 |
| 7 | Western Kentucky | 2 | 77 | 372 | 4.83 | 4 | 38.50 | 186.00 |
| 8 | UAB | 1 | 41 | 269 | 6.56 | 5 | 41.00 | 269.00 |
| 9 | Louisiana Tech | 2 | 89 | 603 | 6.78 | 9 | 44.50 | 301.50 |