2022 Conference USA Leaders Total Defense - Games in August/September Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 4 | 432 | 916 | 307 | 1348 | 4.39 | 337.0 |
| 2 | UAB | 3 | 500 | 543 | 220 | 1043 | 4.74 | 347.7 |
| 3 | Middle Tennessee | 5 | 539 | 1422 | 376 | 1961 | 5.22 | 392.2 |
| 4 | UTEP | 5 | 881 | 784 | 313 | 1665 | 5.32 | 333.0 |
| 5 | Florida Atlantic | 5 | 739 | 1269 | 340 | 2008 | 5.91 | 401.6 |
| 6 | UTSA | 5 | 938 | 1268 | 366 | 2206 | 6.03 | 441.2 |
| 7 | Louisiana Tech | 4 | 922 | 851 | 282 | 1773 | 6.29 | 443.3 |
| 8 | North Texas | 5 | 1034 | 1310 | 371 | 2344 | 6.32 | 468.8 |
| 9 | Rice | 4 | 619 | 784 | 210 | 1403 | 6.68 | 350.8 |
| 10 | Florida International | 3 | 557 | 1053 | 223 | 1610 | 7.22 | 536.7 |
| 11 | Charlotte | 5 | 1268 | 1532 | 357 | 2800 | 7.84 | 560.0 |