2021 Wyoming Cowboys Total Defense Split Stats through 01/10/2022
| Split | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G |
|---|---|---|---|---|---|---|---|
| All Games | 13 | 2349 | 2467 | 892 | 4816 | 5.40 | 370.5 |
| at Home | 6 | 886 | 1060 | 397 | 1946 | 4.90 | 324.3 |
| on Road/Neutral Site | 7 | 1463 | 1407 | 495 | 2870 | 5.80 | 410.0 |
| in Wins | 7 | 1263 | 1451 | 497 | 2714 | 5.46 | 387.7 |
| in Losses | 6 | 1086 | 1016 | 395 | 2102 | 5.32 | 350.3 |
| vs. Conference | 8 | 1437 | 1384 | 539 | 2821 | 5.23 | 352.6 |
| vs. Non-Conference | 5 | 912 | 1083 | 353 | 1995 | 5.65 | 399.0 |
| vs. Ranked (AP) | 1 | 181 | 181 | 73 | 362 | 4.96 | 362.0 |
| vs. Unranked (AP) | 12 | 2168 | 2286 | 819 | 4454 | 5.44 | 371.2 |
| vs. FBS (I-A) | 12 | 2228 | 2267 | 833 | 4495 | 5.40 | 374.6 |
| vs. FCS (I-AA) | 1 | 121 | 200 | 59 | 321 | 5.44 | 321.0 |
| vs. FBS Winning | 5 | 959 | 845 | 361 | 1804 | 5.00 | 360.8 |
| vs. FBS Non-Winning | 7 | 1269 | 1422 | 472 | 2691 | 5.70 | 384.4 |
| vs. FBS Power 5 | 0 | 0 | 0 | 0 | 0 | - | - |
| vs. FBS non-Power 5 | 12 | 2228 | 2267 | 833 | 4495 | 5.40 | 374.6 |
| in August/September | 4 | 593 | 746 | 275 | 1339 | 4.87 | 334.8 |
| in October | 4 | 759 | 468 | 258 | 1227 | 4.76 | 306.8 |
| in November | 4 | 678 | 916 | 281 | 1594 | 5.67 | 398.5 |
| in December/January | 1 | 319 | 337 | 78 | 656 | 8.41 | 656.0 |