2021 Wyoming Cowboys Opponent First Down Split Stats through 01/10/2022
| Split | G | Rush | Pass | Penalty | Total |
|---|---|---|---|---|---|
| All Games | 13 | 121 | 117 | 25 | 263 |
| at Home | 6 | 47 | 53 | 11 | 111 |
| on Road/Neutral Site | 7 | 74 | 64 | 14 | 152 |
| in Wins | 7 | 66 | 67 | 18 | 151 |
| in Losses | 6 | 55 | 50 | 7 | 112 |
| vs. Conference | 8 | 70 | 77 | 10 | 157 |
| vs. Non-Conference | 5 | 51 | 40 | 15 | 106 |
| vs. Ranked (AP) | 1 | 7 | 14 | 2 | 23 |
| vs. Unranked (AP) | 12 | 114 | 103 | 23 | 240 |
| vs. FBS (I-A) | 12 | 117 | 107 | 22 | 246 |
| vs. FCS (I-AA) | 1 | 4 | 10 | 3 | 17 |
| vs. FBS Winning | 5 | 45 | 51 | 6 | 102 |
| vs. FBS Non-Winning | 7 | 72 | 56 | 16 | 144 |
| vs. FBS Power 5 | 0 | 0 | 0 | 0 | 0 |
| vs. FBS non-Power 5 | 12 | 117 | 107 | 22 | 246 |
| in August/September | 4 | 34 | 32 | 11 | 77 |
| in October | 4 | 36 | 24 | 4 | 64 |
| in November | 4 | 34 | 53 | 6 | 93 |
| in December/January | 1 | 17 | 8 | 4 | 29 |