2021 FBS Independents Leaders Sacks - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Notre Dame | 10 | 33.0 | 234 | 3.30 |
| 2 | Connecticut | 3 | 5.0 | 24 | 1.67 |
| 3 | New Mexico State | 2 | 3.0 | 28 | 1.50 |
| 3 | Liberty | 2 | 3.0 | 21 | 1.50 |
| 5 | BYU | 7 | 10.0 | 90 | 1.43 |
| 6 | Army | 3 | 4.0 | 22 | 1.33 |
| 7 | Massachusetts | 3 | 2.0 | 11 | 0.67 |