2021 Independent Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Liberty | 2 | 370 | 401 | 123 | 771 | 6.27 | 385.5 |
| 2 | New Mexico State | 2 | 495 | 799 | 149 | 1294 | 8.68 | 647.0 |
| 3 | Army | 3 | 573 | 808 | 181 | 1381 | 7.63 | 460.3 |
| 4 | Massachusetts | 3 | 838 | 817 | 209 | 1655 | 7.92 | 551.7 |
| 5 | Connecticut | 3 | 422 | 1055 | 251 | 1477 | 5.88 | 492.3 |
| 6 | BYU | 7 | 1257 | 1865 | 475 | 3122 | 6.57 | 446.0 |
| 7 | Notre Dame | 10 | 1378 | 2371 | 704 | 3749 | 5.33 | 374.9 |