2021 Independent Leaders Rushing Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Notre Dame | 10 | 341 | 1378 | 4.04 | 11 | 34.10 | 137.80 |
| 2 | Connecticut | 3 | 118 | 422 | 3.58 | 5 | 39.33 | 140.67 |
| 3 | BYU | 7 | 232 | 1257 | 5.42 | 15 | 33.14 | 179.57 |
| 4 | Liberty | 2 | 81 | 370 | 4.57 | 5 | 40.50 | 185.00 |
| 5 | Army | 3 | 103 | 573 | 5.56 | 8 | 34.33 | 191.00 |
| 6 | New Mexico State | 2 | 77 | 495 | 6.43 | 6 | 38.50 | 247.50 |
| 7 | Massachusetts | 3 | 131 | 838 | 6.40 | 13 | 43.67 | 279.33 |