2021 Independent Leaders Interceptions - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Kyle Hamilton | Notre Dame | JR | S | 5 | 3 | 0 | 0 | 0.60 |
| 1 | DJ Brown | Notre Dame | JR | S | 10 | 3 | 31 | 0 | 0.30 |
| 3 | Payton Wilgar | BYU | SO | LB | 6 | 2 | 24 | 0 | 0.33 |
| 3 | Malik Moore | BYU | JR | DB | 7 | 2 | 23 | 0 | 0.29 |
| 3 | Jack Kiser | Notre Dame | SO | LB | 10 | 2 | 109 | 2 | 0.20 |
| 3 | Cam Hart | Notre Dame | SO | CB | 10 | 2 | 32 | 0 | 0.20 |
| 7 | Stan Cross | UConn | SO | DB | 2 | 1 | 0 | 0 | 0.50 |
| 7 | J.J. Dervil | NMSU | FR | ATH | 2 | 1 | 0 | 0 | 0.50 |
| 7 | Jackson Mitchell | UConn | SO | LB | 3 | 1 | 2 | 0 | 0.33 |
| 7 | Chaz Ah You | BYU | JR | LB | 5 | 1 | 4 | 0 | 0.20 |
| 7 | Hayden Livingston | BYU | SO | DB | 6 | 1 | 0 | 0 | 0.17 |
| 7 | Max Tooley | BYU | SO | LB | 6 | 1 | 0 | 0 | 0.17 |
| 7 | Drew Jensen | BYU | SO | LB | 7 | 1 | 0 | 0 | 0.14 |
| 7 | Drew White | Notre Dame | SR | LB | 9 | 1 | 48 | 1 | 0.11 |
| 7 | Ramon Henderson | Notre Dame | SO | CB | 9 | 1 | 0 | 0 | 0.11 |
| 7 | Bo Bauer | Notre Dame | SR | LB | 10 | 1 | 79 | 0 | 0.10 |
| 7 | Clarence Lewis | Notre Dame | SO | CB | 10 | 1 | 4 | 0 | 0.10 |
| 7 | TaRiq Bracy | Notre Dame | SR | CB | 10 | 1 | 0 | 0 | 0.10 |