2021 Mid-American Conference Leaders First Downs - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Western Michigan | 2 | 11 | 27 | 6 | 44 | 22.0 |
| 2 | Akron | 1 | 5 | 8 | 4 | 17 | 17.0 |
| 2 | Ohio | 1 | 5 | 7 | 4 | 16 | 16.0 |
| 4 | Toledo | 1 | 4 | 9 | 3 | 16 | 16.0 |
| 5 | Miami (Ohio) | 1 | 9 | 6 | 2 | 17 | 17.0 |
| 5 | Kent State | 1 | 8 | 7 | 2 | 17 | 17.0 |
| 5 | Northern Illinois | 1 | 6 | 3 | 2 | 11 | 11.0 |