2021 Mid-American Conference Leaders Scoring Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Buffalo | 1 | 4 | 0 | 4 | 0 | 0 | 28 | 28.0 |
| 1 | Northern Illinois | 2 | 12 | 0 | 12 | 0 | 0 | 84 | 42.0 |
| 3 | Miami (Ohio) | 1 | 4 | 1 | 4 | 0 | 0 | 31 | 31.0 |
| 4 | Bowling Green | 2 | 6 | 2 | 6 | 0 | 0 | 48 | 24.0 |
| 4 | Eastern Michigan | 1 | 4 | 2 | 4 | 0 | 0 | 34 | 34.0 |
| 4 | Central Michigan | 3 | 14 | 2 | 14 | 0 | 0 | 104 | 34.7 |
| 4 | Western Michigan | 2 | 12 | 2 | 10 | 0 | 0 | 88 | 44.0 |
| 4 | Akron | 2 | 16 | 2 | 15 | 0 | 1 | 119 | 59.5 |
| 9 | Kent State | 3 | 14 | 3 | 13 | 0 | 1 | 108 | 36.0 |
| 9 | Ball State | 1 | 5 | 3 | 5 | 0 | 0 | 44 | 44.0 |
| 11 | Ohio | 2 | 7 | 4 | 6 | 1 | 1 | 64 | 32.0 |