2021 Mid-American Conference Leaders Total Defense - Games in December/January Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Central Michigan | 1 | 13 | 227 | 66 | 240 | 3.64 | 240.0 |
| 2 | Western Michigan | 1 | 121 | 121 | 54 | 242 | 4.48 | 242.0 |
| 3 | Miami (Ohio) | 1 | 89 | 228 | 64 | 317 | 4.95 | 317.0 |
| 4 | Toledo | 1 | 159 | 276 | 85 | 435 | 5.12 | 435.0 |
| 5 | Northern Illinois | 2 | 394 | 511 | 117 | 905 | 7.74 | 452.5 |
| 6 | Kent State | 2 | 677 | 229 | 139 | 906 | 6.52 | 453.0 |
| 7 | Ball State | 1 | 259 | 205 | 62 | 464 | 7.48 | 464.0 |
| 8 | Eastern Michigan | 1 | 233 | 295 | 61 | 528 | 8.66 | 528.0 |