2021 Mid-American Conference Leaders Total Defense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Western Michigan | 11 | 1476 | 1792 | 623 | 3268 | 5.25 | 297.1 |
| 2 | Akron | 11 | 2750 | 2237 | 722 | 4987 | 6.91 | 453.4 |
| 3 | Ohio | 11 | 2006 | 2619 | 782 | 4625 | 5.91 | 420.5 |
| 4 | Buffalo | 12 | 2339 | 2651 | 787 | 4990 | 6.34 | 415.8 |
| 5 | Miami (Ohio) | 12 | 1650 | 2598 | 808 | 4248 | 5.26 | 354.0 |
| 6 | Bowling Green | 12 | 2254 | 2234 | 850 | 4488 | 5.28 | 374.0 |
| 7 | Toledo | 12 | 1837 | 2266 | 858 | 4103 | 4.78 | 341.9 |
| 8 | Northern Illinois | 13 | 2630 | 3099 | 860 | 5729 | 6.66 | 440.7 |
| 9 | Central Michigan | 13 | 1551 | 3422 | 889 | 4973 | 5.59 | 382.5 |
| 10 | Eastern Michigan | 13 | 2599 | 3070 | 902 | 5669 | 6.28 | 436.1 |
| 11 | Ball State | 13 | 2293 | 3110 | 926 | 5403 | 5.83 | 415.6 |
| 12 | Kent State | 13 | 2676 | 3512 | 991 | 6188 | 6.24 | 476.0 |