2021 Mid-American Conference Leaders Rushing Defense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Central Michigan | 5 | 144 | 404 | 2.81 | 5 | 28.80 | 80.80 |
| 2 | Western Michigan | 5 | 154 | 619 | 4.02 | 5 | 30.80 | 123.80 |
| 3 | Buffalo | 4 | 163 | 667 | 4.09 | 8 | 40.75 | 166.75 |
| 4 | Toledo | 5 | 200 | 670 | 3.35 | 3 | 40.00 | 134.00 |
| 5 | Bowling Green | 4 | 178 | 696 | 3.91 | 8 | 44.50 | 174.00 |
| 6 | Akron | 4 | 132 | 759 | 5.75 | 13 | 33.00 | 189.75 |
| 7 | Miami (Ohio) | 5 | 210 | 933 | 4.44 | 10 | 42.00 | 186.60 |
| 8 | Ball State | 5 | 213 | 959 | 4.50 | 9 | 42.60 | 191.80 |
| 9 | Eastern Michigan | 5 | 195 | 1011 | 5.18 | 11 | 39.00 | 202.20 |
| 10 | Ohio | 4 | 189 | 1134 | 6.00 | 13 | 47.25 | 283.50 |
| 11 | Northern Illinois | 5 | 199 | 1159 | 5.82 | 18 | 39.80 | 231.80 |
| 12 | Kent State | 5 | 197 | 1200 | 6.09 | 14 | 39.40 | 240.00 |