2021 Mid-American Conference Leaders Rushing Defense - On 2nd Down through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Toledo | 13 | 158 | 446 | 2.82 | 1 | 51 | 25 | 12 | 2 |
| 2 | Western Michigan | 13 | 137 | 566 | 4.13 | 7 | 74 | 35 | 17 | 5 |
| 3 | Ohio | 12 | 148 | 623 | 4.21 | 9 | 58 | 39 | 19 | 4 |
| 4 | Central Michigan | 13 | 145 | 531 | 3.66 | 5 | 32 | 40 | 20 | 4 |
| 4 | Miami (Ohio) | 13 | 155 | 548 | 3.54 | 2 | 50 | 40 | 16 | 4 |
| 6 | Buffalo | 12 | 163 | 730 | 4.48 | 8 | 47 | 44 | 25 | 7 |
| 7 | Bowling Green | 12 | 169 | 631 | 3.73 | 8 | 34 | 53 | 12 | 3 |
| 8 | Akron | 12 | 158 | 810 | 5.13 | 7 | 32 | 55 | 28 | 5 |
| 9 | Ball State | 13 | 174 | 688 | 3.95 | 8 | 48 | 58 | 21 | 3 |
| 10 | Kent State | 14 | 192 | 1032 | 5.38 | 14 | 64 | 62 | 31 | 12 |
| 11 | Eastern Michigan | 13 | 171 | 971 | 5.68 | 10 | 60 | 68 | 31 | 10 |
| 12 | Northern Illinois | 14 | 189 | 1059 | 5.60 | 13 | 51 | 69 | 38 | 11 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||