2021 Big Ten Conference Leaders Sacks - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Ohio State | 2 | 11.0 | 74 | 5.50 |
| 2 | Iowa | 2 | 10.0 | 54 | 5.00 |
| 2 | Maryland | 1 | 5.0 | 39 | 5.00 |
| 4 | Northwestern | 1 | 4.0 | 24 | 4.00 |
| 5 | Wisconsin | 3 | 9.0 | 76 | 3.00 |
| 5 | Michigan State | 1 | 3.0 | 21 | 3.00 |
| 5 | Rutgers | 1 | 3.0 | 14 | 3.00 |
| 8 | Purdue | 2 | 5.0 | 27 | 2.50 |
| 9 | Minnesota | 2 | 4.0 | 32 | 2.00 |
| 9 | Illinois | 2 | 4.0 | 27 | 2.00 |
| 11 | Indiana | 2 | 3.0 | 15 | 1.50 |
| 12 | Michigan | 2 | 2.0 | 8 | 1.00 |
| 12 | Penn State | 1 | 1.0 | 9 | 1.00 |