2021 Big Ten Conference Leaders Sacks - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Michigan State | 11 | 38.0 | 279 | 3.46 |
| 2 | Michigan | 12 | 32.0 | 205 | 2.67 |
| 3 | Wisconsin | 10 | 30.0 | 203 | 3.00 |
| 4 | Maryland | 11 | 24.0 | 180 | 2.18 |
| 5 | Ohio State | 11 | 25.0 | 177 | 2.27 |
| 6 | Illinois | 10 | 27.0 | 166 | 2.70 |
| 6 | Penn State | 11 | 23.0 | 166 | 2.09 |
| 8 | Iowa | 12 | 21.0 | 160 | 1.75 |
| 9 | Purdue | 11 | 21.0 | 154 | 1.91 |
| 10 | Minnesota | 11 | 21.0 | 152 | 1.91 |
| 11 | Nebraska | 10 | 19.0 | 144 | 1.90 |
| 12 | Rutgers | 11 | 15.0 | 104 | 1.36 |
| 13 | Indiana | 9 | 12.0 | 96 | 1.33 |
| 14 | Northwestern | 10 | 12.0 | 67 | 1.20 |