2021 Big Ten Conference Leaders Interceptions - Games in August/September Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Iowa | 4 | 6 | 132 | 2 | 1.50 |
| 2 | Penn State | 4 | 5 | 77 | 1 | 1.25 |
| 2 | Nebraska | 5 | 5 | 33 | 0 | 1.00 |
| 4 | Ohio State | 4 | 4 | 150 | 2 | 1.00 |
| 4 | Michigan State | 4 | 4 | 62 | 0 | 1.00 |
| 4 | Maryland | 4 | 4 | 10 | 0 | 1.00 |
| 7 | Rutgers | 4 | 3 | 67 | 1 | 0.75 |
| 7 | Minnesota | 4 | 3 | 51 | 0 | 0.75 |
| 7 | Northwestern | 4 | 3 | 26 | 0 | 0.75 |
| 7 | Illinois | 5 | 3 | 0 | 0 | 0.60 |
| 11 | Purdue | 4 | 2 | 9 | 0 | 0.50 |
| 12 | Wisconsin | 3 | 1 | 6 | 0 | 0.33 |
| 12 | Michigan | 4 | 1 | 27 | 0 | 0.25 |
| 12 | Indiana | 4 | 1 | 0 | 0 | 0.25 |