2021 Big Ten Conference Leaders Passes Defended - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Iowa | 12 | 22 | 46 | 68 | 5.67 |
| 1 | Michigan State | 10 | 7 | 46 | 53 | 5.30 |
| 3 | Illinois | 11 | 8 | 43 | 51 | 4.64 |
| 4 | Michigan | 10 | 5 | 42 | 47 | 4.70 |
| 5 | Ohio State | 9 | 11 | 37 | 48 | 5.33 |
| 5 | Minnesota | 11 | 7 | 37 | 44 | 4.00 |
| 7 | Penn State | 8 | 10 | 36 | 46 | 5.75 |
| 7 | Maryland | 9 | 5 | 36 | 41 | 4.56 |
| 9 | Rutgers | 9 | 6 | 33 | 39 | 4.33 |
| 10 | Purdue | 9 | 8 | 32 | 40 | 4.44 |
| 11 | Northwestern | 9 | 6 | 28 | 34 | 3.78 |
| 12 | Wisconsin | 10 | 15 | 26 | 41 | 4.10 |
| 13 | Indiana | 7 | 1 | 23 | 24 | 3.43 |
| 14 | Nebraska | 7 | 6 | 17 | 23 | 3.29 |