2021 Big Ten Conference Leaders First Downs - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Ohio State | 4 | 42 | 65 | 3 | 110 | 27.5 |
| 2 | Purdue | 4 | 26 | 63 | 9 | 98 | 24.5 |
| 3 | Penn State | 4 | 35 | 51 | 5 | 91 | 22.8 |
| 4 | Maryland | 4 | 49 | 50 | 2 | 101 | 25.3 |
| 5 | Michigan State | 4 | 45 | 48 | 7 | 100 | 25.0 |
| 6 | Indiana | 3 | 29 | 40 | 6 | 75 | 25.0 |
| 7 | Iowa | 4 | 23 | 36 | 5 | 64 | 16.0 |
| 8 | Wisconsin | 4 | 35 | 35 | 7 | 77 | 19.3 |
| 9 | Nebraska | 3 | 33 | 34 | 4 | 71 | 23.7 |
| 10 | Rutgers | 4 | 41 | 33 | 4 | 78 | 19.5 |
| 11 | Illinois | 3 | 28 | 30 | 8 | 66 | 22.0 |
| 12 | Michigan | 4 | 56 | 26 | 4 | 86 | 21.5 |
| 13 | Minnesota | 4 | 47 | 20 | 3 | 70 | 17.5 |
| 14 | Northwestern | 3 | 39 | 19 | 4 | 62 | 20.7 |