2021 Big Ten Conference Leaders Rushing Defense - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Penn State | 1 | 26 | 69 | 2.65 | 1 | 26.00 | 69.00 |
| 1 | Michigan State | 1 | 26 | 72 | 2.77 | 0 | 26.00 | 72.00 |
| 3 | Minnesota | 2 | 55 | 126 | 2.29 | 3 | 27.50 | 63.00 |
| 4 | Indiana | 2 | 56 | 211 | 3.77 | 4 | 28.00 | 105.50 |
| 5 | Northwestern | 1 | 31 | 179 | 5.77 | 1 | 31.00 | 179.00 |
| 6 | Nebraska | 1 | 33 | 135 | 4.09 | 0 | 33.00 | 135.00 |
| 7 | Wisconsin | 3 | 100 | 198 | 1.98 | 2 | 33.33 | 66.00 |
| 8 | Ohio State | 2 | 68 | 149 | 2.19 | 0 | 34.00 | 74.50 |
| 8 | Purdue | 2 | 68 | 235 | 3.46 | 1 | 34.00 | 117.50 |
| 8 | Michigan | 2 | 68 | 287 | 4.22 | 1 | 34.00 | 143.50 |
| 11 | Rutgers | 1 | 36 | 113 | 3.14 | 2 | 36.00 | 113.00 |
| 12 | Illinois | 2 | 76 | 298 | 3.92 | 3 | 38.00 | 149.00 |
| 13 | Iowa | 2 | 89 | 175 | 1.97 | 1 | 44.50 | 87.50 |
| 14 | Maryland | 1 | 47 | 150 | 3.19 | 0 | 47.00 | 150.00 |