2021 Big Ten Conference Leaders Scoring Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Minnesota | 11 | 23 | 9 | 20 | 0 | 0 | 185 | 16.8 |
| 1 | Iowa | 12 | 28 | 18 | 26 | 0 | 0 | 248 | 20.7 |
| 1 | Ohio State | 11 | 36 | 6 | 35 | 0 | 0 | 269 | 24.5 |
| 1 | Michigan State | 11 | 34 | 16 | 32 | 0 | 0 | 284 | 25.8 |
| 1 | Northwestern | 10 | 41 | 17 | 39 | 0 | 0 | 336 | 33.6 |
| 1 | Indiana | 9 | 40 | 12 | 38 | 0 | 1 | 316 | 35.1 |
| 7 | Wisconsin | 10 | 17 | 10 | 14 | 1 | 0 | 148 | 14.8 |
| 7 | Illinois | 10 | 24 | 15 | 21 | 1 | 0 | 212 | 21.2 |
| 7 | Purdue | 11 | 33 | 11 | 31 | 1 | 0 | 264 | 24.0 |
| 7 | Nebraska | 10 | 30 | 15 | 29 | 1 | 3 | 262 | 26.2 |
| 7 | Rutgers | 11 | 40 | 9 | 37 | 1 | 0 | 306 | 27.8 |
| 12 | Maryland | 11 | 49 | 13 | 46 | 2 | 0 | 383 | 34.8 |
| 13 | Penn State | 11 | 21 | 15 | 18 | 3 | 0 | 195 | 17.7 |
| 14 | Michigan | 12 | 25 | 13 | 20 | 5 | 0 | 219 | 18.3 |