2021 Big Ten Conference Leaders Tackles For Loss - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Isaiah Gay | Illinois | SR | OLB | 1 | 5.5 | 12 | 5.50 |
| 2 | Arnold Ebiketie | Penn State | SR | DE | 4 | 8.0 | 33 | 2.00 |
| 3 | Nick Herbig | Wisconsin | SO | OLB | 3 | 5.5 | 26 | 1.83 |
| 4 | Zach VanValkenburg | Iowa | SR | DL | 2 | 3.5 | 23 | 1.75 |
| 5 | Micah McFadden | Indiana | SR | LB | 5 | 8.5 | 66 | 1.70 |
| 6 | Aidan Hutchinson | Michigan | SR | DE | 4 | 6.0 | 33 | 1.50 |
| 7 | George Karlaftis | Purdue | JR | DE | 4 | 5.0 | 14 | 1.25 |
| 8 | Jesse Luketa | Penn State | SR | DE | 5 | 6.0 | 16 | 1.20 |
| 9 | Jack Sanborn | Wisconsin | SR | ILB | 3 | 3.5 | 6 | 1.17 |
| 10 | Ryder Anderson | Indiana | SR | DL | 5 | 5.0 | 26 | 1.00 |
| 10 | Curtis Jacobs | Penn State | SO | LB | 5 | 5.0 | 11 | 1.00 |
| 10 | David Ojabo | Michigan | JR | LB | 4 | 4.0 | 32 | 1.00 |
| 10 | Sam Okuayinonu | Maryland | SR | DL | 4 | 4.0 | 22 | 1.00 |
| 10 | Ami Finau | Maryland | SR | DL | 4 | 4.0 | 10 | 1.00 |
| 10 | Christian Izien | Rutgers | JR | DB | 4 | 4.0 | 10 | 1.00 |
| 10 | Leo Chenal | Wisconsin | JR | ILB | 3 | 3.0 | 11 | 1.00 |
| 10 | Trill Carter | Minnesota | SO | DL | 2 | 2.0 | 8 | 1.00 |
| 10 | Jer'Zhan Newton | Illinois | FR | DL | 1 | 1.0 | 11 | 1.00 |
| 10 | Devon Witherspoon | Illinois | SO | DB | 1 | 1.0 | 4 | 1.00 |
| 20 | Luke Reimer | Nebraska | SO | ILB | 5 | 4.0 | 19 | 0.80 |
| 21 | Smith Vilbert | Penn State | SO | DE | 4 | 3.0 | 17 | 0.75 |
| 21 | Lawtez Rogers | Maryland | SR | DL | 4 | 3.0 | 10 | 0.75 |
| 21 | Kourt Williams II | Ohio State | FR | SAF | 4 | 3.0 | 10 | 0.75 |
| 21 | JoJo Domann | Nebraska | SR | OLB | 4 | 3.0 | 9 | 0.75 |
| 21 | Logan Lee | Iowa | SO | DL | 2 | 1.5 | 4 | 0.75 |
| 26 | Garrett Nelson | Nebraska | SO | OLB | 5 | 3.5 | 21 | 0.70 |
| 26 | Nick Tarburton | Penn State | JR | DE | 5 | 3.5 | 18 | 0.70 |
| 26 | Ben Stille | Nebraska | SR | DL | 5 | 3.5 | 5 | 0.70 |
| 29 | Desmond Igbinosun | Rutgers | FR | DB | 3 | 2.0 | 18 | 0.67 |
| 29 | Olakunle Fatukasi | Rutgers | SR | LB | 3 | 2.0 | 14 | 0.67 |
| 29 | Jacub Panasiuk | Mich St | SR | DE | 3 | 2.0 | 13 | 0.67 |
| 29 | Jacob Slade | Mich St | JR | DT | 3 | 2.0 | 11 | 0.67 |
| 29 | Noah Burks | Wisconsin | SR | OLB | 3 | 2.0 | 10 | 0.67 |
| 29 | C.J. Goetz | Wisconsin | JR | OLB | 3 | 2.0 | 9 | 0.67 |
| 29 | Matt Henningsen | Wisconsin | SR | DE | 3 | 2.0 | 8 | 0.67 |
| 29 | Scott Nelson | Wisconsin | SR | S | 3 | 2.0 | 5 | 0.67 |
| 29 | Noah Harvey | Mich St | SR | LB | 3 | 2.0 | 4 | 0.67 |
| 29 | Rod Heard II | N'western | SO | DB | 3 | 2.0 | 4 | 0.67 |
| 29 | Angelo Grose | Mich St | SO | S | 3 | 2.0 | 3 | 0.67 |
| 40 | Kydran Jenkins | Purdue | FR | DE | 4 | 2.5 | 15 | 0.63 |
| 40 | Jaylan Alexander | Purdue | SR | LB | 4 | 2.5 | 14 | 0.63 |
| 40 | DaMarcus Mitchell | Purdue | SR | DE | 4 | 2.5 | 13 | 0.63 |
| 43 | Ty Robinson | Nebraska | FR | DL | 5 | 3.0 | 21 | 0.60 |
| 43 | Weston Kramer | Indiana | SR | DL | 5 | 3.0 | 12 | 0.60 |
| 45 | Caleb Tannor | Nebraska | JR | OLB | 5 | 2.5 | 12 | 0.50 |
| 45 | Mosiah Nasili-Kite | Maryland | JR | DL | 4 | 2.0 | 12 | 0.50 |
| 45 | Jaylen Harrell | Michigan | SO | LB | 4 | 2.0 | 3 | 0.50 |
| 45 | Brandon Wright | Mich St | JR | DE | 3 | 1.5 | 10 | 0.50 |
| 45 | Haskell Garrett | Ohio State | SR | DT | 3 | 1.5 | 8 | 0.50 |
| 45 | Drew Beesley | Mich St | SR | DE | 3 | 1.5 | 5 | 0.50 |
Note: To qualify, player must have played in 75% of his team's games.