2021 Big Ten Conference Leaders Passes Defended - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Ji'Ayir Brown | Penn State | SR | S | 4 | 3 | 2 | 5 | 1.25 |
| 2 | Jakorian Bennett | Maryland | SR | DB | 4 | 2 | 5 | 7 | 1.75 |
| 2 | Max Melton | Rutgers | FR | DB | 4 | 2 | 5 | 7 | 1.75 |
| 2 | Deontai Williams | Nebraska | SR | S | 3 | 2 | 2 | 4 | 1.33 |
| 2 | Matt Hankins | Iowa | SR | DB | 3 | 2 | 1 | 3 | 1.00 |
| 2 | Ronnie Hickman | Ohio State | SO | SAF | 4 | 2 | 0 | 2 | 0.50 |
| 7 | Angelo Grose | Mich St | SO | S | 4 | 1 | 3 | 4 | 1.00 |
| 7 | Cameron Martinez | Ohio State | FR | SAF | 4 | 1 | 3 | 4 | 1.00 |
| 7 | Jermari Harris | Iowa | SO | DB | 2 | 1 | 2 | 3 | 1.50 |
| 7 | Kerby Joseph | Illinois | JR | DB | 3 | 1 | 2 | 3 | 1.00 |
| 7 | Luke Reimer | Nebraska | SO | ILB | 3 | 1 | 2 | 3 | 1.00 |
| 7 | Tyler Nubin | Minnesota | JR | DB | 4 | 1 | 2 | 3 | 0.75 |
| 7 | Mariano Sori-Marin | Minnesota | SR | LB | 4 | 1 | 2 | 3 | 0.75 |
| 7 | Daequan Hardy | Penn State | SO | CB | 4 | 1 | 2 | 3 | 0.75 |
| 7 | Marcelino McCrary-Ball | Indiana | SR | DB | 3 | 1 | 1 | 2 | 0.67 |
| 7 | JoJo Domann | Nebraska | SR | OLB | 3 | 1 | 1 | 2 | 0.67 |
| 7 | Nick Cross | Maryland | JR | DB | 4 | 1 | 1 | 2 | 0.50 |
| 7 | Xavier Henderson | Mich St | SR | S | 4 | 1 | 1 | 2 | 0.50 |
| 7 | Ronald Williams | Mich St | SR | CB | 4 | 1 | 1 | 2 | 0.50 |
| 7 | Cam Allen | Purdue | JR | S | 4 | 1 | 1 | 2 | 0.50 |
| 7 | Donte Burton | Wisconsin | JR | CB | 1 | 1 | 0 | 1 | 1.00 |
| 7 | Keith Randolph Jr. | Illinois | FR | DL | 2 | 1 | 0 | 1 | 0.50 |
| 7 | Chris Bergin | N'western | SR | LB | 3 | 1 | 0 | 1 | 0.33 |
| 7 | Bryce Jackson | N'western | SR | DB | 3 | 1 | 0 | 1 | 0.33 |
| 7 | Brandon Joseph | N'western | SO | SAF | 3 | 1 | 0 | 1 | 0.33 |
| 7 | Cody Simon | Ohio State | SO | LB | 3 | 1 | 0 | 1 | 0.33 |
| 7 | Zane Greene | Purdue | JR | S | 3 | 1 | 0 | 1 | 0.33 |
| 7 | Tre Avery | Rutgers | SR | DB | 3 | 1 | 0 | 1 | 0.33 |
| 7 | Seth Benson | Iowa | JR | LB | 4 | 1 | 0 | 1 | 0.25 |
| 7 | Cal Haladay | Mich St | FR | LB | 4 | 1 | 0 | 1 | 0.25 |
| 7 | Gemon Green | Michigan | SR | DB | 4 | 1 | 0 | 1 | 0.25 |
| 7 | Michael Dixon | Minnesota | SO | DB | 4 | 1 | 0 | 1 | 0.25 |
| 7 | Jesse Luketa | Penn State | SR | DE | 4 | 1 | 0 | 1 | 0.25 |
| 7 | John Torchio | Wisconsin | JR | S | 4 | 1 | 0 | 1 | 0.25 |