2021 American Athletic Conference Leaders Sacks - Games on the Road/Neutral Site Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Houston | 9 | 29.0 | 198 | 3.22 |
| 2 | Cincinnati | 7 | 16.0 | 105 | 2.29 |
| 3 | East Carolina | 6 | 11.0 | 83 | 1.83 |
| 4 | Navy | 6 | 12.0 | 82 | 2.00 |
| 5 | Tulsa | 7 | 14.0 | 77 | 2.00 |
| 6 | Tulane | 6 | 12.0 | 69 | 2.00 |
| 7 | SMU | 6 | 12.0 | 65 | 2.00 |
| 8 | UCF | 6 | 10.0 | 49 | 1.67 |
| 9 | Memphis | 5 | 5.0 | 38 | 1.00 |
| 10 | Temple | 6 | 4.0 | 30 | 0.67 |
| 11 | South Florida | 6 | 3.0 | 17 | 0.50 |