2021 American Athletic Conference Leaders First Downs - Games in August/September Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | SMU | 4 | 49 | 54 | 5 | 108 | 27.0 |
| 2 | UCF | 3 | 43 | 42 | 5 | 90 | 30.0 |
| 3 | Tulane | 4 | 39 | 45 | 10 | 94 | 23.5 |
| 4 | USF | 4 | 38 | 31 | 7 | 76 | 19.0 |
| 5 | Memphis | 4 | 34 | 41 | 9 | 84 | 21.0 |
| 5 | Navy | 3 | 34 | 9 | 3 | 46 | 15.3 |
| 7 | Tulsa | 4 | 33 | 47 | 8 | 88 | 22.0 |
| 8 | Cincinnati | 3 | 28 | 29 | 8 | 65 | 21.7 |
| 9 | Houston | 4 | 27 | 47 | 9 | 83 | 20.8 |
| 9 | Temple | 4 | 27 | 32 | 7 | 66 | 16.5 |
| 11 | East Carolina | 4 | 22 | 44 | 7 | 73 | 18.3 |