2021 American Athletic Conference Leaders Rushing Offense - Games in August/September Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Navy | 3 | 165 | 575 | 3.48 | 3 | 55.00 | 191.67 |
| 2 | South Florida | 4 | 167 | 632 | 3.78 | 9 | 41.75 | 158.00 |
| 3 | UCF | 3 | 124 | 757 | 6.10 | 8 | 41.33 | 252.33 |
| 4 | SMU | 4 | 159 | 929 | 5.84 | 4 | 39.75 | 232.25 |
| 5 | Tulsa | 4 | 150 | 751 | 5.01 | 6 | 37.50 | 187.75 |
| 6 | Memphis | 4 | 147 | 750 | 5.10 | 8 | 36.75 | 187.50 |
| 6 | Tulane | 4 | 147 | 623 | 4.24 | 6 | 36.75 | 155.75 |
| 8 | Houston | 4 | 146 | 512 | 3.51 | 9 | 36.50 | 128.00 |
| 9 | East Carolina | 4 | 135 | 518 | 3.84 | 6 | 33.75 | 129.50 |
| 9 | Temple | 4 | 135 | 483 | 3.58 | 7 | 33.75 | 120.75 |
| 11 | Cincinnati | 3 | 99 | 495 | 5.00 | 9 | 33.00 | 165.00 |