2021 American Athletic Conference Leaders First Downs - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | SMU | 7 | 74 | 98 | 8 | 180 | 25.7 |
| 1 | Houston | 8 | 63 | 107 | 10 | 180 | 22.5 |
| 3 | Tulsa | 7 | 78 | 78 | 14 | 170 | 24.3 |
| 4 | UCF | 8 | 74 | 64 | 11 | 149 | 18.6 |
| 5 | East Carolina | 5 | 60 | 66 | 7 | 133 | 26.6 |
| 6 | Cincinnati | 5 | 48 | 53 | 5 | 106 | 21.2 |
| 7 | Memphis | 4 | 34 | 48 | 6 | 88 | 22.0 |
| 8 | Temple | 6 | 34 | 47 | 6 | 87 | 14.5 |
| 9 | South Florida | 3 | 48 | 20 | 4 | 72 | 24.0 |
| 10 | Tulane | 2 | 24 | 20 | 0 | 44 | 22.0 |
| 11 | Navy | 2 | 32 | 5 | 2 | 39 | 19.5 |