2021 American Athletic Conference Leaders Interceptions - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Tulsa | 5 | 6 | 71 | 1 | 1.20 |
| 2 | East Carolina | 6 | 7 | 24 | 0 | 1.17 |
| 3 | Cincinnati | 8 | 7 | 118 | 1 | 0.88 |
| 4 | Memphis | 7 | 6 | 26 | 0 | 0.86 |
| 5 | Houston | 5 | 4 | 45 | 1 | 0.80 |
| 6 | Tulane | 9 | 7 | 62 | 0 | 0.78 |
| 7 | UCF | 4 | 3 | 31 | 0 | 0.75 |
| 8 | South Florida | 8 | 5 | 161 | 1 | 0.63 |
| 9 | Navy | 10 | 6 | 23 | 0 | 0.60 |
| 9 | Temple | 5 | 3 | 45 | 0 | 0.60 |
| 11 | SMU | 4 | 2 | 11 | 0 | 0.50 |