2021 American Athletic Conference Leaders Interceptions - Games at Home Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | South Florida | 6 | 7 | 222 | 1 | 1.17 |
| 2 | Tulane | 6 | 8 | 156 | 1 | 1.33 |
| 3 | East Carolina | 6 | 10 | 121 | 2 | 1.67 |
| 3 | Cincinnati | 7 | 7 | 121 | 1 | 1.00 |
| 5 | UCF | 7 | 9 | 91 | 0 | 1.29 |
| 6 | SMU | 6 | 8 | 77 | 0 | 1.33 |
| 7 | Tulsa | 6 | 5 | 44 | 0 | 0.83 |
| 8 | Navy | 6 | 5 | 23 | 0 | 0.83 |
| 9 | Memphis | 7 | 6 | 16 | 0 | 0.86 |
| 10 | Houston | 5 | 3 | 0 | 0 | 0.60 |
| 11 | Temple | 6 | 3 | -3 | 0 | 0.50 |