2021 American Athletic Conference Leaders Passing Defense - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Temple | 9 | 252 | 159 | 63.1 | 1895 | 7.5 | 23 | 4 | 153.22 | 28.0 | 210.6 |
| 2 | Cincinnati | 11 | 316 | 172 | 54.4 | 1815 | 5.7 | 8 | 12 | 103.45 | 28.7 | 165.0 |
| 3 | East Carolina | 10 | 293 | 174 | 59.4 | 2167 | 7.4 | 14 | 13 | 128.42 | 29.3 | 216.7 |
| 4 | Tulsa | 10 | 319 | 182 | 57.1 | 2288 | 7.2 | 11 | 9 | 123.03 | 31.9 | 228.8 |
| 5 | Houston | 11 | 340 | 187 | 55.0 | 2209 | 6.5 | 16 | 14 | 116.86 | 30.9 | 200.8 |
| 6 | South Florida | 9 | 280 | 191 | 68.2 | 2377 | 8.5 | 20 | 7 | 158.09 | 31.1 | 264.1 |
| 7 | Tulane | 9 | 302 | 197 | 65.2 | 2422 | 8.0 | 21 | 6 | 151.58 | 33.6 | 269.1 |
| 8 | UCF | 10 | 340 | 202 | 59.4 | 1995 | 5.9 | 8 | 9 | 111.17 | 34.0 | 199.5 |
| 9 | Navy | 12 | 306 | 204 | 66.7 | 2618 | 8.6 | 15 | 7 | 150.14 | 25.5 | 218.2 |
| 10 | Memphis | 10 | 335 | 208 | 62.1 | 2393 | 7.1 | 18 | 8 | 135.04 | 33.5 | 239.3 |
| 10 | SMU | 10 | 340 | 208 | 61.2 | 2848 | 8.4 | 23 | 7 | 149.74 | 34.0 | 284.8 |