2021 American Athletic Conference Leaders Opponent First Downs - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | SMU | 1 | 6 | 13 | 1 | 20 | 20.0 |
| 2 | East Carolina | 1 | 10 | 4 | 2 | 16 | 16.0 |
| 2 | Temple | 2 | 22 | 11 | 2 | 35 | 17.5 |
| 2 | Tulsa | 2 | 21 | 20 | 2 | 43 | 21.5 |
| 2 | Cincinnati | 2 | 25 | 20 | 2 | 47 | 23.5 |
| 2 | Memphis | 1 | 6 | 18 | 2 | 26 | 26.0 |
| 7 | Houston | 2 | 12 | 15 | 3 | 30 | 15.0 |
| 7 | UCF | 2 | 16 | 24 | 3 | 43 | 21.5 |
| 9 | South Florida | 2 | 24 | 25 | 4 | 53 | 26.5 |
| 10 | Tulane | 2 | 29 | 29 | 7 | 65 | 32.5 |