2021 American Athletic Conference Leaders Scoring Defense - Games in October Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | University of Houston | 4 | 12 | 3 | 10 | 1 | 0 | 93 | 23.3 |
| 1 | East Carolina University | 4 | 12 | 3 | 9 | 2 | 0 | 94 | 23.5 |
| 3 | University of Cincinnati | 5 | 8 | 4 | 7 | 0 | 1 | 69 | 13.8 |
| 3 | University of Memphis | 4 | 14 | 4 | 14 | 0 | 0 | 110 | 27.5 |
| 3 | The University of Tulsa | 4 | 16 | 4 | 13 | 2 | 0 | 125 | 31.3 |
| 3 | Temple University | 4 | 22 | 4 | 20 | 1 | 0 | 166 | 41.5 |
| 7 | University of Central Florida | 5 | 15 | 5 | 15 | 0 | 0 | 120 | 24.0 |
| 7 | Southern Methodist University | 4 | 14 | 5 | 12 | 0 | 0 | 111 | 27.8 |
| 7 | U.S. Naval Academy | 5 | 18 | 5 | 17 | 0 | 0 | 140 | 28.0 |
| 7 | University of South Florida | 4 | 15 | 5 | 11 | 0 | 0 | 116 | 29.0 |
| 11 | Tulane University | 4 | 23 | 6 | 22 | 0 | 0 | 178 | 44.5 |