2021 American Athletic Conference Leaders Passing Defense - Games in August/September Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 3 | 97 | 43 | 44.3 | 482 | 5.0 | 2 | 6 | 80.50 | 32.3 | 160.7 |
| 2 | Temple | 4 | 87 | 46 | 52.9 | 431 | 5.0 | 4 | 3 | 102.75 | 21.8 | 107.8 |
| 3 | Houston | 4 | 63 | 35 | 55.6 | 464 | 7.4 | 2 | 3 | 118.39 | 15.8 | 116.0 |
| 4 | UCF | 3 | 129 | 78 | 60.5 | 828 | 6.4 | 6 | 3 | 125.09 | 43.0 | 276.0 |
| 5 | SMU | 4 | 158 | 89 | 56.3 | 1224 | 7.7 | 9 | 6 | 132.61 | 39.5 | 306.0 |
| 6 | Memphis | 4 | 197 | 130 | 66.0 | 1394 | 7.1 | 10 | 1 | 141.16 | 49.3 | 348.5 |
| 7 | East Carolina | 4 | 152 | 95 | 62.5 | 1307 | 8.6 | 6 | 5 | 141.18 | 38.0 | 326.8 |
| 8 | Navy | 3 | 74 | 46 | 62.2 | 669 | 9.0 | 2 | 2 | 141.61 | 24.7 | 223.0 |
| 9 | Tulsa | 4 | 124 | 81 | 65.3 | 990 | 8.0 | 6 | 3 | 143.52 | 31.0 | 247.5 |
| 10 | South Florida | 4 | 125 | 79 | 63.2 | 1088 | 8.7 | 9 | 3 | 155.27 | 31.3 | 272.0 |
| 11 | Tulane | 4 | 129 | 90 | 69.8 | 1073 | 8.3 | 10 | 5 | 157.47 | 32.3 | 268.3 |