2021 American Athletic Conference Leaders Rushing Defense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Houston | 13 | 417 | 1305 | 3.13 | 11 | 32.08 | 100.38 |
| 2 | Tulsa | 9 | 328 | 1138 | 3.47 | 10 | 36.44 | 126.44 |
| 3 | Cincinnati | 11 | 461 | 1617 | 3.51 | 13 | 41.91 | 147.00 |
| 4 | Tulane | 8 | 315 | 1142 | 3.63 | 13 | 39.38 | 142.75 |
| 5 | SMU | 10 | 359 | 1324 | 3.69 | 13 | 35.90 | 132.40 |
| 6 | Navy | 9 | 307 | 1200 | 3.91 | 19 | 34.11 | 133.33 |
| 7 | UCF | 12 | 437 | 1734 | 3.97 | 18 | 36.42 | 144.50 |
| 8 | Memphis | 11 | 452 | 1808 | 4.00 | 19 | 41.09 | 164.36 |
| 9 | Temple | 10 | 477 | 2150 | 4.51 | 26 | 47.70 | 215.00 |
| 10 | East Carolina | 10 | 340 | 1710 | 5.03 | 17 | 34.00 | 171.00 |
| 11 | USF | 8 | 289 | 1588 | 5.49 | 14 | 36.13 | 198.50 |