2021 American Athletic Conference Leaders Opponent First Downs - Games Lost Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 1 | 16 | 10 | 1 | 27 | 27.0 |
| 2 | Houston | 2 | 11 | 15 | 3 | 29 | 14.5 |
| 3 | East Carolina | 5 | 38 | 46 | 9 | 93 | 18.6 |
| 4 | SMU | 4 | 27 | 58 | 9 | 94 | 23.5 |
| 5 | UCF | 4 | 56 | 47 | 6 | 109 | 27.3 |
| 6 | Tulsa | 6 | 52 | 59 | 13 | 124 | 20.7 |
| 7 | Memphis | 6 | 70 | 64 | 8 | 142 | 23.7 |
| 8 | Navy | 8 | 65 | 81 | 7 | 153 | 19.1 |
| 9 | Temple | 9 | 117 | 81 | 11 | 209 | 23.2 |
| 10 | Tulane | 10 | 91 | 131 | 18 | 240 | 24.0 |
| 11 | USF | 10 | 111 | 130 | 15 | 256 | 25.6 |