2021 American Athletic Conference Leaders Scoring Defense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Houston | 5 | 9 | 4 | 9 | 0 | 0 | 75 | 15.0 |
| 2 | Cincinnati | 5 | 11 | 3 | 10 | 0 | 0 | 85 | 17.0 |
| 3 | SMU | 4 | 11 | 6 | 8 | 0 | 0 | 92 | 23.0 |
| 4 | Navy | 4 | 15 | 3 | 14 | 1 | 2 | 119 | 29.8 |
| 4 | East Carolina | 4 | 15 | 5 | 14 | 0 | 0 | 119 | 29.8 |
| 6 | Temple | 4 | 16 | 2 | 16 | 0 | 1 | 120 | 30.0 |
| 7 | UCF | 5 | 16 | 3 | 16 | 0 | 0 | 121 | 24.2 |
| 8 | Memphis | 4 | 16 | 6 | 13 | 0 | 0 | 127 | 31.8 |
| 9 | Tulsa | 5 | 16 | 9 | 16 | 0 | 0 | 139 | 27.8 |
| 9 | South Florida | 4 | 19 | 2 | 19 | 0 | 0 | 139 | 34.8 |
| 11 | Tulane | 4 | 20 | 4 | 17 | 0 | 0 | 149 | 37.3 |