2021 American Athletic Conference Leaders Scoring Defense - Games vs. Conference Teams Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | University of Cincinnati | 9 | 17 | 10 | 15 | 1 | 1 | 151 | 16.8 |
| 2 | University of Houston | 9 | 27 | 7 | 24 | 2 | 0 | 211 | 23.4 |
| 3 | East Carolina University | 8 | 26 | 5 | 21 | 2 | 0 | 196 | 24.5 |
| 4 | University of Central Florida | 8 | 24 | 10 | 24 | 0 | 0 | 198 | 24.8 |
| 5 | The University of Tulsa | 8 | 26 | 8 | 23 | 2 | 0 | 207 | 25.9 |
| 6 | U.S. Naval Academy | 8 | 28 | 8 | 26 | 1 | 0 | 220 | 27.5 |
| 7 | University of Memphis | 8 | 28 | 9 | 27 | 1 | 0 | 224 | 28.0 |
| 8 | Southern Methodist University | 8 | 33 | 7 | 30 | 0 | 0 | 249 | 31.1 |
| 9 | Tulane University | 8 | 33 | 10 | 31 | 0 | 0 | 259 | 32.4 |
| 10 | University of South Florida | 8 | 36 | 9 | 32 | 0 | 1 | 277 | 34.6 |
| 11 | Temple University | 8 | 43 | 10 | 40 | 1 | 0 | 330 | 41.3 |