2021 American Athletic Conference Leaders Opponent First Downs - All Games through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Houston | 14 | 80 | 110 | 28 | 218 | 15.6 |
| 2 | Navy | 12 | 86 | 105 | 14 | 205 | 17.1 |
| 3 | Cincinnati | 14 | 124 | 120 | 24 | 268 | 19.1 |
| 4 | East Carolina | 12 | 100 | 115 | 18 | 233 | 19.4 |
| 5 | Tulsa | 13 | 93 | 134 | 26 | 253 | 19.5 |
| 6 | SMU | 12 | 80 | 139 | 21 | 240 | 20.0 |
| 7 | UCF | 13 | 111 | 139 | 24 | 274 | 21.1 |
| 8 | Temple | 12 | 143 | 108 | 17 | 268 | 22.3 |
| 9 | Tulane | 12 | 107 | 144 | 21 | 272 | 22.7 |
| 10 | Memphis | 12 | 125 | 138 | 16 | 279 | 23.3 |
| 11 | USF | 12 | 118 | 150 | 16 | 284 | 23.7 |