2021 American Athletic Conference Leaders Sacks - Games in December/January Only through 01/10/2022
| Name | Team | Yr | Pos | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Joel Dublanko | Cincinnati | SR | LB | 2 | 2.0 | 10 | 1.00 |
| 2 | Curtis Brooks | Cincinnati | SR | DL | 2 | 1.5 | 14 | 0.75 |
| 3 | Logan Hall | Houston | JR | DL | 1 | 1.0 | 10 | 1.00 |
| 3 | Ahmad Gardner | Cincinnati | JR | CB | 2 | 1.0 | 9 | 0.50 |
| 3 | Jaxon Player | Tulsa | SR | DL | 1 | 1.0 | 7 | 1.00 |
| 3 | Jowon Briggs | Cincinnati | SO | DL | 2 | 1.0 | 7 | 0.50 |
| 3 | David Anenih | Houston | SR | DL | 2 | 1.0 | 7 | 0.50 |
| 3 | Darrian Beavers | Cincinnati | SR | LB | 2 | 1.0 | 6 | 0.50 |
| 3 | Nicholas Straw | Navy | JR | RDR | 1 | 1.0 | 4 | 1.00 |
| 3 | Malik Vann | Cincinnati | SR | DL | 2 | 1.0 | 4 | 0.50 |
| 3 | Jeremiah Jean-Baptiste | UCF | JR | LB | 1 | 1.0 | 2 | 1.00 |
| 3 | Wilson Huber | Cincinnati | SR | LB | 2 | 1.0 | 2 | 0.50 |
| 3 | Cam Goode | UCF | JR | DL | 1 | 1.0 | 1 | 1.00 |
| 14 | Myjai Sanders | Cincinnati | SR | DL | 2 | 0.5 | 4 | 0.25 |
| 14 | Marcus Brown | Cincinnati | SR | DT | 2 | 0.5 | 3 | 0.25 |
| 14 | Jabari Taylor | Cincinnati | SR | DL | 2 | 0.5 | 3 | 0.25 |