2021 American Athletic Conference Leaders Interceptions - All Games through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Ja'Quan McMillian | ECU | SO | CB | 12 | 5 | 42 | 1 | 0.42 |
| 2 | Marcus Jones | Houston | SR | CB | 13 | 5 | 2 | 0 | 0.38 |
| 3 | Macon Clark | Tulane | JR | S | 12 | 4 | 78 | 0 | 0.33 |
| 3 | Warren Saba | ECU | SR | SAF | 12 | 4 | 31 | 0 | 0.33 |
| 3 | TieNeal Martin | Tulsa | SR | S | 12 | 4 | 0 | 0 | 0.33 |
| 6 | Deshawn Pace | Cincinnati | SO | LB | 14 | 4 | 78 | 0 | 0.29 |
| 7 | Travon Fuller | Tulsa | SR | CB | 13 | 3 | 60 | 0 | 0.23 |
| 7 | Arquon Bush | Cincinnati | JR | CB | 13 | 3 | 7 | 0 | 0.23 |
| 9 | Isaiah Nwokobia | SMU | FR | S | 9 | 2 | 19 | 0 | 0.22 |
| 10 | Coby Bryant | Cincinnati | SR | CB | 14 | 3 | 95 | 1 | 0.21 |
| 10 | Ahmad Gardner | Cincinnati | JR | CB | 14 | 3 | 7 | 0 | 0.21 |
| 12 | Jalen Ware | Temple | JR | SAF | 10 | 2 | 20 | 0 | 0.20 |
| 13 | Mekhi LaPointe | S Florida | SR | DB | 11 | 2 | 50 | 0 | 0.18 |
| 14 | Antonio Grier | S Florida | SR | LB | 12 | 2 | 69 | 1 | 0.17 |
| 14 | Kevin Henry | Tulane | SR | LB | 12 | 2 | 53 | 1 | 0.17 |
| 14 | Gleson Sprewell | Houston | SR | S | 12 | 2 | 44 | 0 | 0.17 |
| 14 | Dyllon Lester | UCF | JR | DB | 12 | 2 | 34 | 0 | 0.17 |
| 14 | Malik Fleming | ECU | SO | CB | 12 | 2 | 31 | 1 | 0.17 |
| 14 | Isaac Slade-Matautia | SMU | JR | LB | 12 | 2 | 27 | 0 | 0.17 |
| 14 | Rodney Owens | Memphis | SR | DB | 12 | 2 | 25 | 0 | 0.17 |
| 14 | Tatum Bethune | UCF | JR | LB | 12 | 2 | 23 | 0 | 0.17 |
| 14 | Trevor Denbow | SMU | SR | S | 12 | 2 | 18 | 0 | 0.17 |
| 14 | Manny Walker | Temple | SR | DE | 12 | 2 | 11 | 1 | 0.17 |
| 14 | Dwayne Boyles | S Florida | SR | LB | 12 | 2 | 4 | 0 | 0.17 |
| 14 | Jacobi Francis | Memphis | SR | DB | 12 | 2 | 1 | 0 | 0.17 |
| 14 | Jadon Canady | Tulane | FR | DB | 12 | 2 | 0 | 0 | 0.17 |
| 27 | Gervarrius Owens | Houston | JR | S | 13 | 2 | 73 | 1 | 0.15 |
| 27 | Divaad Wilson | UCF | JR | DB | 13 | 2 | 25 | 0 | 0.15 |
| 29 | Alex Hogan | Houston | JR | CB | 14 | 2 | 91 | 1 | 0.14 |
| 29 | Ja'von Hicks | Cincinnati | SR | S | 14 | 2 | 18 | 0 | 0.14 |
| 29 | Bryan Cook | Cincinnati | SR | S | 14 | 2 | 0 | 0 | 0.14 |
| 32 | Juan Powell | ECU | FR | SAF | 9 | 1 | 4 | 0 | 0.11 |
| 32 | Johnny Hodges | Navy | JR | LB | 9 | 1 | 0 | 0 | 0.11 |
| 34 | Brock Nichols | S Florida | SR | S | 10 | 1 | 38 | 0 | 0.10 |
| 34 | Matthew Hill | S Florida | SO | S | 10 | 1 | 27 | 0 | 0.10 |
| 34 | Mbiti Williams Jr. | Navy | FR | CB | 10 | 1 | 7 | 0 | 0.10 |
| 34 | Justin Hodges | UCF | SO | DB | 10 | 1 | 0 | 0 | 0.10 |
| 38 | Teagan Wilk | ECU | FR | SAF | 11 | 1 | 6 | 0 | 0.09 |
| 38 | Jamal Glenn | Navy | SR | CB | 11 | 1 | 1 | 0 | 0.09 |
| 38 | Tre'mon Morris-Brash | UCF | JR | DL | 11 | 1 | 0 | 0 | 0.09 |
| 38 | Keyshawn Paul | Temple | JR | CB | 11 | 1 | 0 | 0 | 0.09 |
| 38 | Taylor Robinson | Navy | JR | BAN | 11 | 1 | 0 | 0 | 0.09 |
| 43 | Justin Wright | Tulsa | JR | LB | 12 | 1 | 55 | 1 | 0.08 |
| 43 | Bryan Massey | SMU | SO | S | 12 | 1 | 48 | 0 | 0.08 |
| 43 | Shawn Dourseau | ECU | SO | SAF | 12 | 1 | 33 | 0 | 0.08 |
| 43 | Freddie Johnson | Temple | SR | CB | 12 | 1 | 25 | 0 | 0.08 |
| 43 | Davonte Brown | UCF | SO | DB | 13 | 1 | 14 | 0 | 0.08 |
| 43 | Quindell Johnson | Memphis | JR | DB | 12 | 1 | 14 | 0 | 0.08 |
| 43 | Derrion Rakestraw | Tulane | SR | S | 12 | 1 | 12 | 0 | 0.08 |
| 43 | Cam Goode | UCF | JR | DL | 13 | 1 | 10 | 0 | 0.08 |
Note: To qualify, player must have played in 75% of his team's games.