2021 Atlantic Coast Conference Leaders Sacks - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Clemson | 1 | 6.0 | 44 | 6.00 |
| 2 | Pittsburgh | 2 | 8.0 | 62 | 4.00 |
| 2 | Florida State | 2 | 8.0 | 26 | 4.00 |
| 4 | Syracuse | 2 | 6.0 | 31 | 3.00 |
| 5 | Virginia Tech | 2 | 5.0 | 32 | 2.50 |
| 6 | Louisville | 2 | 4.0 | 31 | 2.00 |
| 6 | Boston College | 2 | 4.0 | 19 | 2.00 |
| 8 | Georgia Tech | 2 | 3.0 | 27 | 1.50 |
| 8 | North Carolina State | 2 | 3.0 | 17 | 1.50 |
| 8 | Wake Forest | 2 | 3.0 | 9 | 1.50 |
| 11 | North Carolina | 2 | 2.0 | 7 | 1.00 |
| 11 | Duke | 1 | 1.0 | 5 | 1.00 |
| 11 | Miami (Florida) | 1 | 1.0 | 2 | 1.00 |