2021 Atlantic Coast Conference Leaders Sacks - Games in November Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Pittsburgh | 4 | 21.0 | 147 | 5.25 |
| 2 | Clemson | 4 | 19.0 | 118 | 4.75 |
| 3 | North Carolina State | 4 | 16.0 | 100 | 4.00 |
| 4 | Miami (Florida) | 4 | 13.0 | 92 | 3.25 |
| 5 | North Carolina | 4 | 12.0 | 81 | 3.00 |
| 6 | Florida State | 4 | 11.0 | 61 | 2.75 |
| 7 | Boston College | 4 | 10.0 | 71 | 2.50 |
| 8 | Louisville | 4 | 9.0 | 64 | 2.25 |
| 9 | Wake Forest | 4 | 8.0 | 49 | 2.00 |
| 10 | Virginia | 3 | 7.0 | 48 | 2.33 |
| 11 | Virginia Tech | 4 | 6.0 | 54 | 1.50 |
| 12 | Georgia Tech | 4 | 5.0 | 30 | 1.25 |
| 13 | Syracuse | 3 | 4.0 | 34 | 1.33 |
| 13 | Duke | 4 | 4.0 | 10 | 1.00 |