2021 Atlantic Coast Conference Leaders Turnover Margin - Games in October Only through 01/10/2022
| Name | G | Fum. Gain | Int. Gain | Total Gain | Fum. Lost | Int. Lost | Total Lost | Margin | Margin/G | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | North Carolina State | 4 | 1 | 4 | 5 | 0 | 0 | 0 | 5 | 1.25 |
| 1 | North Carolina | 4 | 1 | 4 | 5 | 0 | 3 | 3 | 2 | 0.50 |
| 1 | Miami (Florida) | 3 | 0 | 3 | 3 | 0 | 4 | 4 | -1 | -0.33 |
| 4 | Wake Forest | 4 | 5 | 1 | 6 | 1 | 2 | 3 | 3 | 0.75 |
| 4 | Pittsburgh | 4 | 0 | 6 | 6 | 1 | 2 | 3 | 3 | 0.75 |
| 4 | Virginia Tech | 4 | 1 | 3 | 4 | 1 | 2 | 3 | 1 | 0.25 |
| 4 | Georgia Tech | 4 | 0 | 1 | 1 | 1 | 6 | 7 | -6 | -1.50 |
| 8 | Clemson | 4 | 4 | 3 | 7 | 2 | 3 | 5 | 2 | 0.50 |
| 8 | Virginia | 4 | 3 | 3 | 6 | 2 | 4 | 6 | 0 | 0.00 |
| 8 | Syracuse | 5 | 1 | 2 | 3 | 2 | 2 | 4 | -1 | -0.20 |
| 11 | Boston College | 4 | 3 | 2 | 5 | 3 | 5 | 8 | -3 | -0.75 |
| 12 | Florida State | 4 | 3 | 5 | 8 | 4 | 1 | 5 | 3 | 0.75 |
| 12 | Duke | 4 | 2 | 2 | 4 | 4 | 4 | 8 | -4 | -1.00 |
| 14 | Louisville | 4 | 1 | 5 | 6 | 5 | 3 | 8 | -2 | -0.50 |