2021 Atlantic Coast Conference Leaders Fumbles Lost - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Fumbles | Fumbles Lost | Fumble Lost % | |
|---|---|---|---|---|---|
| 1 | Georgia Tech | 4 | 2 | 1 | 50.00 |
| 1 | North Carolina | 4 | 2 | 1 | 50.00 |
| 1 | Virginia Tech | 2 | 2 | 1 | 50.00 |
| 1 | Wake Forest | 3 | 2 | 2 | 100.00 |
| 5 | Duke | 2 | 3 | 2 | 66.67 |
| 5 | North Carolina State | 2 | 3 | 2 | 66.67 |
| 5 | Syracuse | 4 | 3 | 2 | 66.67 |
| 8 | Pittsburgh | 3 | 4 | 1 | 25.00 |
| 8 | Clemson | 4 | 4 | 2 | 50.00 |
| 10 | Virginia | 4 | 5 | 2 | 40.00 |
| 10 | Louisville | 5 | 5 | 3 | 60.00 |
| 12 | Boston College | 3 | 6 | 3 | 50.00 |
| 12 | Miami (Florida) | 4 | 6 | 3 | 50.00 |
| 14 | Florida State | 4 | 8 | 5 | 62.50 |