2021 Atlantic Coast Conference Leaders Passes Defended - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Florida State | 4 | 6 | 15 | 21 | 5.25 |
| 1 | North Carolina State | 4 | 6 | 15 | 21 | 5.25 |
| 1 | Duke | 4 | 5 | 16 | 21 | 5.25 |
| 4 | Clemson | 5 | 7 | 19 | 26 | 5.20 |
| 5 | Boston College | 4 | 6 | 12 | 18 | 4.50 |
| 5 | Wake Forest | 4 | 6 | 12 | 18 | 4.50 |
| 5 | Virginia | 4 | 2 | 16 | 18 | 4.50 |
| 8 | Pittsburgh | 5 | 3 | 18 | 21 | 4.20 |
| 9 | Miami (Florida) | 4 | 2 | 10 | 12 | 3.00 |
| 10 | Virginia Tech | 5 | 4 | 8 | 12 | 2.40 |
| 11 | Syracuse | 4 | 1 | 8 | 9 | 2.25 |
| 12 | Georgia Tech | 4 | 2 | 6 | 8 | 2.00 |
| 13 | Louisville | 5 | 3 | 6 | 9 | 1.80 |
| 14 | North Carolina | 4 | 2 | 4 | 6 | 1.50 |