2021 Atlantic Coast Conference Leaders Rushing Offense - From Own 40 to Opponent's 40 Yard Line through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Syracuse | 12 | 121 | 890 | 7.36 | 6 | 56 | 43 | 30 | 13 |
| 2 | Louisville | 13 | 141 | 853 | 6.05 | 3 | 52 | 42 | 28 | 11 |
| 2 | North Carolina | 13 | 123 | 682 | 5.54 | 3 | 53 | 40 | 26 | 6 |
| 2 | Duke | 12 | 138 | 643 | 4.66 | 3 | 59 | 31 | 17 | 6 |
| 2 | Miami (Florida) | 12 | 100 | 534 | 5.34 | 3 | 57 | 31 | 16 | 5 |
| 6 | Wake Forest | 14 | 143 | 702 | 4.91 | 2 | 48 | 41 | 18 | 5 |
| 7 | Virginia Tech | 13 | 139 | 706 | 5.08 | 1 | 50 | 38 | 25 | 8 |
| 7 | Clemson | 13 | 115 | 581 | 5.05 | 1 | 59 | 34 | 18 | 6 |
| 7 | Pittsburgh | 14 | 122 | 574 | 4.70 | 1 | 58 | 37 | 19 | 5 |
| 7 | Virginia | 12 | 81 | 505 | 6.23 | 1 | 49 | 31 | 24 | 7 |
| 7 | Georgia Tech | 12 | 120 | 489 | 4.08 | 1 | 50 | 28 | 16 | 6 |
| 7 | North Carolina State | 12 | 118 | 427 | 3.62 | 1 | 46 | 25 | 16 | 5 |
| 7 | Florida State | 12 | 96 | 412 | 4.29 | 1 | 53 | 27 | 18 | 3 |
| 14 | Boston College | 12 | 123 | 543 | 4.41 | 0 | 47 | 37 | 16 | 7 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||