2021 Atlantic Coast Conference Leaders Scoring Defense - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 12 | 22 | 12 | 18 | 1 | 1 | 190 | 15.8 |
| 2 | North Carolina State | 11 | 28 | 11 | 28 | 0 | 0 | 229 | 20.8 |
| 3 | Boston College | 11 | 32 | 13 | 31 | 0 | 2 | 266 | 24.2 |
| 4 | Pittsburgh | 13 | 42 | 10 | 38 | 1 | 1 | 324 | 24.9 |
| 5 | Syracuse | 11 | 34 | 18 | 30 | 2 | 0 | 292 | 26.5 |
| 6 | Virginia Tech | 12 | 41 | 11 | 38 | 1 | 0 | 319 | 26.6 |
| 7 | Florida State | 11 | 38 | 11 | 33 | 2 | 0 | 298 | 27.1 |
| 8 | Louisville | 12 | 43 | 18 | 40 | 0 | 0 | 352 | 29.3 |
| 9 | Wake Forest | 13 | 49 | 15 | 47 | 1 | 0 | 388 | 29.8 |
| 10 | Miami (Florida) | 11 | 40 | 19 | 36 | 3 | 1 | 341 | 31.0 |
| 11 | North Carolina | 12 | 50 | 17 | 44 | 4 | 0 | 403 | 33.6 |
| 12 | Virginia | 11 | 48 | 15 | 45 | 1 | 1 | 382 | 34.7 |
| 13 | Georgia Tech | 11 | 48 | 16 | 45 | 2 | 0 | 385 | 35.0 |
| 14 | Duke | 11 | 58 | 19 | 55 | 0 | 0 | 460 | 41.8 |